Riluzole for Amyotrophic Lateral Sclerosis Treatment

Role of Riluzole in Amyotrophic Lateral Sclerosis

Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND).

BACKGROUND Riluzole 100 mg probably prolongs survival in patients with amyotrophic lateral sclerosis by about two months and the safety of the drug is not a major concern. The evidence from randomized controlled trials indicates that patients taking riluzole probably survive longer than patients taking placebo. The beneficial effects are very modest and the drug is expensive. Adverse effects fr...

The cost utility analysis of riluzole for the treatment of amyotrophic lateral sclerosis in the UK.

This study reports the results of a long-term economic evaluation of riluzole in the treatment of amyotrophic lateral sclerosis (ALS) versus best supportive care in the United Kingdom. The aim was to assess the cost implications of the life extension offered by riluzole through cost utility analysis based on patient assessed utilities of different health states.A Markov model was used to assess...

Stem Cells may Beat Riluzole in Treatment of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis, commonly known as Lou Gehrig's disease, or simply ALS, is a neurodegenerative disease that slowly kills its victims within a few years after diagnosis. This is a complex disease in which every motor neuron in the body is killed over a relatively short time period within 3 years or so, thus killing the victim. This disease can be classified into three main categori...

Etiology and treatment of amyotrophic lateral sclerosis.

BACKGROUND To date all researchers conclude that the etiology of Amyotrophic lateral sclerosis (ALS) is not known. On the contrary, since August 2009, we believe that disease is of ischemic origin in the anterior surface of the medulla oblongata. MATERIAL AND METHOD We present our surgical experience into 45 patients with ALS (bulbar form in 36 cases and spinal form in 9). Preoperative MRI sc...